life sciences innovations

featured innovations

plant based diets

long acting injectables

 

  

nutraceuticals delivery

 next-gen controlled release polymers

    

diagnostic films overview

      

related published innovation papers

title/description authors related technologies
The aim of this study was to develop a hydrophilic oral controlled release system (CRS) using the amorphous form of gliclazide, a BCS class II compound, listed on the WHO list of essential medicines. For this purpose, spray-dried dispersions (SDDs) of gliclazide were produced using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) or copovidone as carrier under fully automated conditions Lu, Zheng, Yonglai Yang, Rae-Ann Covington, Yunxia Vivian Bi, Thomas Dürig, and Reza Fassihi polysaccharides, acetylenics
Cocrystals, Coamorphous Phases and Coordination Complexes of γ-and ε-Lactams Hall, Amy V., Luke I. Chambers, Osama M. Musa, and Jonathan W. Steed acetylenics
Development of carvedilol-cyclodextrin inclusion complexes using fluid-bed granulation: a novel solid-state complexation alternative with technological advantages Ellen C P Alonso, Karina Riccomini, Luis Antônio D Silva, Daniela Galter, Eliana M Lima, Thomas Durig, Stephania F Taveira, Felipe Terra Martins, Marcílio S S Cunha-Filho, Ricardo N Marreto polysaccharide
The preparation of graft copolymers of cellulose and cellulose derivatives using ATRP under homogeneous reaction conditions Joubert, F., Musa, O. M., Hodgson, D. R. W., & Cameron polysaccharide
Cyclodextrin-Efavirenz Complexes Investigated by Solid State and Solubility Studies Braga, Susana S., Karyna Lysenko, Firas El-Saleh, and Filipe A.A. Paz polysaccharide
Radiochromic Film as a Tool for Development of Sun Protection Duev, A., Dueva-Koganov, O. V., Shih, S., Crohn, R., Aydin, R., & Menchon, M.  acetylenics
Is It Possible to Publish a Calibration Function for Radiochromic Film?     Chan, Maria F., Lewis D., Xiang Yu acetylenics
Inclusion Compound of Efavirenz and γ-Cyclodextrin: Solid State Studies and Effect on Solubility Braga, S. S., El-Saleh, F., Lysenko, K., & Paz, F. A. A. acetylenics

Hot Melt Extrudates Formulated Using Design Space: One Simple Process for Both Palatability and Dissolution Rate Improvement

This work aimed at obtaining an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and dissolution rate by combining different polymers using hot melt extrusion (HME), according to a simplex centroid mixture design. For this, the polymers Plasdone® (poly(1-vinylpyrrolidone-co-vinyl acetate) [PVP/VA]), Klucel® ELF (2-hydroxypropyl ether cellulose [HPC]), and Soluplus® (SOL, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol) were processed using a laboratory HME equipment operating without recirculation at constant temperature.    

 Malaquias, L. F. B., Schulte, H. L., Chaker, J. A., Karan, K., Durig, T., Marreto, R. N., Gratieri, T., Gelfuso, G. M., & Cunha-Filho polysaccharides, acetylenics
Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms     Mogen AB, Chen F, Ahn SJ, Burne RA, Wang D, et al. functional molecules

Assessment of Polymeric Nanoparticles to Enhance Oral Bioavailability and Antioxidant Activity of Resveratrol

To enhance oral bioavailability and antioxidant potential of resveratrol by fabricating the resveratrol encapsulated oral eudragit® E100 based polymeric nano-delivery system.    
 

 Hasija, R., S. Chaurasia, and Swati Gupta acetylenics
Resveratrol-Loaded Poly(d,l-Lactide-Co-Glycolide) Microspheres Integrated in a Hyaluronic Acid Injectable Hydrogel for Cartilage Regeneration Wang, X., Li, X., Duffy, P., McMahon, S., Wang, X., Lyu, J., Xu, Q., A, S., Chen, N.N., Bi, V., Dürig, T. and Wang, W. polyesters

Fabrication of Taste-Masked Donut-Shaped Tablets Via Fused Filament Fabrication 3D Printing Paired with Hot-Melt Extrusion Techniques

The formulations without Eudragit E PO (F6) and with Eudragit E PO (F7) filaments exhibited the desired hardness with a “k” value of 48.30 ± 3.52 and 45.47 ± 3.51 g/mm3 (n = 10), respectively, and were successfully printed.

 Wang, H., Dumpa, N., Bandari, S. Durig, H acetylenics

Investigation of the interactions of enteric and hydrophilic polymers to enhance dissolution of griseofulvin following hot melt extrusion processing

Binary, ternary and quaternary dispersions containing GF, enteric polymer (Eudragit L100-55 or AQOAT-LF) and/or vinyl pyrrolidone-based polymer (Plasdone K-12 povidone or S-630 copovidone) were processed by HME.

 Ryan C Bennett, Justin M Keen, Yunxia (Vivian) Bi, Stuart Porter, Thomas Dürig, James W McGinity acetylenics

 

 back to research & development home page>