benecel™ hypromellose

chemistry: cellulosics

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Benecel™ products are high purity, water-souble, nonionic cellulose ethers.  Benecel™ hypromellose (hydroxypropyl-methylcellulose or HPMC) is a versatile excipient with a variety of applications.  HPMC is the most widely used polymer in hydrophilic matrix systems with widespread use in controlled-release dosage forms.  The Benecel™ family of pharmaceutical products, including Benecel™ XR and XRF HPMC, custom grades of Benecel™ HPMC, and Benecel™ DC HPMC, provides a full portfolio to support the controlled release of a broad range of APIs and manufacturing processes.

Benecel™ XR and XRF HPMC grades:

Benecel™ XR and XRF are high-viscosity grades of HPMC with optimized polymer structure and particle morphology for use in matrix controlled-release systems.

Features and Benefits:

- Optimized polymer structure and particle morphology
- Consistent particle size distribution and bulk density
- Enhanced compactibility at high tableting speeds vs standard grades
- Fine particle size grades available (XRF)


Custom Grades of HPMC for Controlled Release:

Achieving a desired drug-release profile has traditionally involved blends of different molecular weights of particular polymers. Blending, however, can increase release-profile variability. Custom grades of Benecel™ HPMC were developed to obviate the need for blending and offer a potential solution to the problem of dissolution variability.

Features and Benefits:

- Increase predictability and reproducibility of drug release profiles
- Decrease research and development time needed to optimize blend ratio
- Decrease manufacturing time- no need to blend and manage multiple raw materials
- Opportunity to develop custom excipients


Directly Compressible HPMC Grades:

Directly compressible (DC) grades enable the production of controlled-release formulations with the convenience of the most widely used tablet-binding mechanism. These Benecel™ DC HPMC grades offer good powder flow, content uniformity, and compressibility, making them well suited for direct compression.

Features and Benefits:

- Improves product flow characteristics
- Reduces processing times
- Identical, stable dissolution profiles compared with “CR” grades
- Improves content uniformity
- Reduces production costs
- Retains tensile strength after double compaction (roller compaction) process


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