parenteral dosage form
solutions that are more than skin deep
Bioresorbable polymers have been commercialized for more than 50 years, however, until now, no manufacturer has offered a single source of three key excipients used to formulate these revolutionary drug delivery systems that are designed to improve patients’ lives.
With the addition of Viatel™ bioresorbable polymers, Ashland provides a comprehensive line of products for parenteral, controlled release drug delivery. Complementary excipients include Aqualon™ CMC PH BET sodium carboxymethyl cellulose, a suspending agent for two-component systems; and Pharmasolve™ n-methyl-2-pyrrolidone, a versatile solubilizer for one-component systems.
Parenteral formulations present unique challenges to formulators. Ashland has products that can help address these challenges.
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Cavitron™ and CAVASOL* HPBCD and HPGCD
The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-ß- or hydroxypropyl-γ-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the Cavitron and CAVASOL HPBCDs and HPGCDs capable ...
Plasdone™ povidone C grades
Ashland offers a comprehensive range of Plasdone povidones (PVP). Plasdone povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation or direct compression. Plasdone K polymers are used in sol...
Pharmasolve™ N-methyl-2-pyrrolidone (NMP) is a versatile solubilizer for one-component systems. It is a water-miscible polar aprotic solvent with high interfacial activity. Pharmasolve™ NMP is manufactured in a facility with ISO 9001:2015 and EXCiPACT GMP certifications. It is used as a drug solubilizer and penetration enhancer in human and animal parenteral dosage forms.
Viatel™ bioresorbable polymers
Ashland offers five families of bioresorbable polymers for parenteral controlled-release drug delivery systems and medical devices. For drug delivery, Ashland offers amorphous homopolymers and copolymers, including: Poly(D,L-lactide) (PDLLA) and Poly(D,L-lactide-co-glycolide) (PLGA). For medical devices, Ashland offers semi-crystalline and amorphous homopolymers and copolymers including: Poly(L-lactide) (PLLA), Poly(ɛ-caprolactone) (PCL) and P...
Vialose™ trehalose dihydrate
who stabilizes your biologic for optimal health? we do a high purity grade of trehalose Vialose™ trehalose dihydrate is Ashland’s brand of trehalose dihydrate, a functional ingredient used to protect and stabilize proteins for biologic medicines and is the newest addition to Ashland’s portfolio of injectable formulations. Vialose™ trehalose dihydrate is a high purity lyoprotect and stabilizer for...