plasdone™ s-630 ultra copovidone

chemistry: vp and derivatives

chemical name: copovidone

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Plasdone™ S-630 Ultra copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrrolidone and vinyl acetate. It is commonly used to enhance the solubility of APIs and increase bioavailability of poorly water-soluble APIs through the formation of melt-extruded or spray-dried solid dispersions. It can also be used as a binder in direct compression, dry granulation, or wet granulation, resulting in hard, non-friable tablets. Plasdone™ S-630 Ultra copovidone is a new and improved version of copovidone. It was designed to provide improved stability in tablet formulations, and processability in hot melt extrusion, and continuous processing.

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features and benefits
  • excellent for oxidative sensitive APIs with greater long-term stability
  • efficient, high throughput, energy saving binder/solubilizer/carrier for hot-melt extrusion and continuous processes with enhanced processability and stability
  • versatile solid dispersion solubilizer/carrier for enhanced bioavailability in both spray-drying and hot-melt extrusion processes
  • superior binder for direct compression and dry granulation resulting in hard, non-friable tablets

  • tablet binding
  • drug solubilization

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