klucel™ xtend hydroxypropylcellulose (HPC) controlled release matrix former

Ashland introduces Klucel™ xtend hydroxypropyl cellulose (HPC) controlled release matrix former, designed to deliver unsurpassed process versatility and release profile efficiency. It is the latest addition to our Klucel™ product line and further expands our controlled-release portfolio.

Until now, there were limited options for managing the release profile of formulations, especially high dose, controlled release formulations. Ashland’s step change klucel™ xtend HPC has been shown to match the release profile of hypromellose controlled-release formulations at half the polymer concentration. The highly reduced polymer concentration achievable with klucel™ xtend HPC offers the possibility of smaller pills or higher dosage, if necessary. This new excipient offers unrivaled versatility across a broad range of APIs in every manufacturing process: dry granulation, wet-granulation, direct compression, and holt-melt extrusion.

The need for hot-melt extrusion (HME) polymers is expected to grow as the pharma industry moves to implement more continuous and sustainable processes. klucel™ xtend HPC is the only cellulosic excipient that provides a compendial extended-release polymer option for plasticizer-free HME.

This oral matrix former is the new gold standard for extended-release tablets.

klucel™ xtend HPC extending your options for

• highly soluble APIs
• high drug load formulations
• melt granulation or HME processing
• increased patient compliance
• complex formulations

features

• high gel strength
• low melt processing temperature
• process versatility

benefits

• consistent release profiles at lower concentrations than hydroxypropyl methylcellulose (HPMC)
• reduced burst effect in highly soluble APIs
• enables the development of smaller tablets and improves consumer usability
• excellent performance in direct compression, wet granulation, dry granulation, and hot melt extrusion
• plasticizer-free HME processability
• meets all compendia for HPC

And submit the literature download form on the right to download more information and data about klucel™ xtend HPC.