Plasdone™ S-630 and S-630 Ultra copovidone

Chemistry: PVP polymers and VP derivatives

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Plasdone™ S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrollidone and vinyl acetate. The pyrrolidone ring is responsible for excellent water solubility, adhesion, film forming and solubilization properties, while the vinyl acetate monomer reduces glass transition temperature (Tg) and hygroscopicity compared to homopolymers of pyrrolidone (PVP). Well-known in the industry as a multipurpose excipient, copovidone functions as a binder, solubilizer/solid dispersion carrier and film former in a variety of pharmaceutical formulations.

features and benefits:

  • superior binder for direct compression and dry granulation resulting in hard, non-friable tabletsversatile solid dispersion solubilizer/carrier for enhanced
  • bioavailability in both spray drying and hot melt extrusion processes

Plasdone™ S-630 Ultra copovidone is a grade of Plasdone S-630 designed to provide better performance in tablet formulations, hot melt extrusion (HME) and continuous processing by offering superior benefits compared to the original Plasdone™ S-630 copovidone.

features and benefits (in addition to the above):

  • provides greater long-term stability for oxidative sensitive APIs
  • efficient, high throughput, energy saving binder/solubilizer/carrier for hot melt extrusion and continuous processes with enhanced processability and stability

 

  

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