plasdone™ s-630 copovidone

chemistry: vp and derivatives

chemical name: copovidone

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Plasdone™ S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrrolidone and vinyl acetate. It is commonly used to enhance the solubility of APIs and increase bioavailability of poorly water-soluble APIs through the formation of melt-extruded or spray-dried solid dispersions. It can also be used as a binder in direct compression, dry granulation, or wet granulation, resulting in hard, non-friable tablets.

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features and benefits
  • excellent thermoplastic properties for HME or direct compression
  • amorphous solid dispersion stabilizer
  • compatible with most plasticizers

  • tablet binding
  • drug solubilization

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