polyplasdone™ xl-10 crospovidone

chemistry: vp and derivatives

chemical name: polyvinylpolypyrollidone

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Polyplasdone™ crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Polyplasdone™ crospovidone particles are granular and porous compared with other superdisintegrants. The high surface area combined with unique chemistry results in high interfacial activity that enhances the dissolution of poorly water-soluble active pharmaceutical ingredients (APIs) in a way that is not possible with other disintegrant technologies.

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features and benefits
  • provides rapid disintegration in wet and dry granulation and direct compression tablet processes
  • combines multiple mechanisms to achieve disintegration at low use levels (2-5 wt%)
  • swells without forming gels that can slow tablet disintegration or dissolution
  • increases tablet breaking force and reduces friability
  • enhances the dissolution of poorly soluble drugs
  • available in Type A and Type B crospovidone grades
  • polyplasdone™ ultra and ultra-10 grades provide the same great performance with very low peroxide levels

  • disintegration
  • drug solubilization
  • suspending agent

region currently available

For country-specific details, please contact your local sales representative.
Asia Pacific / China / Europe Middle East & Africa / Latin America / North America

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