plasdone™ k-25 povidone

chemistry: vp and derivatives

chemical name: polyvinylpyrrolidone

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Plasdone™ povidones are a family of water-soluble polymers based on N-vinylpyrrolidone that combine a unique set of properties for application in a wide variety of dosage forms. Plasdone™ povidones are commonly used as binders for the development of tablet formulations, whether manufactured by wet granulation, dry granulation, or direct compression. Plasdone™ K polymers are used in solid dispersion formulations to enhance the solubility of active pharmaceutical ingredients and increase bioavailability. Plasdone™ K grades are also used to inhibit recrystallization in liquid soft gels and free sugar syrups.

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features and benefits
  • highly adhesive polymer- excellent tablet binding capacity at low concentrations producing hard, non-friable tablets
  • excellent solubility in water and non-polar solvents- can be added as an aqueous or non-aqueous solution to wet granulation tablet processes
  • dissolves quickly- does not delay disintegration or dissolution
  • low solution viscosity- workable solution viscosity at high polymer levels makes it easy to use in granulation and other manufacturing equipment
  • non-ionic- solution- viscosity is not affected by changes in pH or the presence of electrolytes, will not form complexes or interact with ionic drug actives
  • interfacially active- acts as a drug solubilizer, inhibits crystallization of drug actives and inactive ingredients, stabilizes suspensions, dispersions and emulsions 
  • controlled nitrite levels for APIs sensitive to nitrosamine formation

applications
  • tablet binding
  • film coating
  • drug solubilization
  • viscosifier

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