Ashland experts share controlled release research in AAPS Journal

New research to help pharmaceutical scientists develop oral controlled release formulations more easily

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Ashland scientists Divya Tewari and Tom Durig have contributed to a chapter in the AAPS book Hydrophilic Matrix Tablets for Oral Controlled Release to help address key issues and subtle nuances involved in developing hydrophilic matrix tablets as an approach to oral controlled release.

Their chapter discusses the application of twin-screw hot-melt extrusion as an enabling technology to overcome well-known, physical limitations of hydrophilic controlled-release matrix tablets manufactured by conventional means, such as direct compression and wet and dry granulation. Case studies are presented that show enhanced tablet compactibility, smaller tablets, and greater drug retardation for hydrophilic matrix tablets comprising up to 75 % highly soluble drug (metformin) made by melt extrusion as opposed to conventional methods.

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