Plasdone™ S-630 copovidone

Plasdone S-630 copovidone is a tablet binder, matrix polymer for solid-dispersion formulations and film former for topical applications. It is commonly used to enhance the solubility of active pharmaceutical ingredients and increase bioavailability of poorly soluble drugs through the formation of melt-extruded or spray-dried solid dispersions.

The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).

Explore other products:  Excipients, Specialty Ingredients

Application Information

Applications

Description

Benefits

Drug Solublization

Plasdone S-630 copovidone provides a matrix to solubilize poorly soluble drugs in melt-extruded or spray-dried solid dispersions. It has application in a wide variety of dosage forms, including oral solid, liquid, and topical formulations.

  • Low Tg for ease of processing in hot-melt extrusion and spray drying
  • Compatible with other ingredients to allow optimization of solid dispersion formulations for stability and delivery
  • Film former for topical applications
Tablet Binding

Plasdone S-630 copovidone is a linear random water-soluble copolymer of N-vinylpyrrolidone and vinyl acetate that combines a unique set of properties for application in a wide variety of dosage forms.

  • High bonding capabilities in granulations
  • Non-ionic to minimize API interactions
  • Increases tablet strength and reduces friability due to high compressibility and excellent adhesive properties
  • Physiologically inert for good safety profile
  • Solubility in aqueous and polar organic solvents adds processing flexibility
Tablet Film Coating

Plasdone S-630 copovidone is a key ingredient in high-solids film coating formulations.

  • Improved film adhesion
  • Increased processing efficiencies

Document Library

Market Information

Markets

Application

Product Types or Functions

Pharmaceutical
Drug Solublization, Tablet Binding, Tablet Film Coating
Matrix Polymer for Solid Dispersions, Tablet Binder