plasdone™ s-630 copovidone
chemistry: vp and derivatives
chemical name: copovidone
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Plasdone™ S-630 copovidone is a 60:40 random, linear copolymer produced by the free radical polymerization of N-vinyl-2-pyrrolidone and vinyl acetate. It is commonly used to enhance the solubility of APIs and increase bioavailability of poorly water-soluble APIs through the formation of melt-extruded or spray-dried solid dispersions. It can also be used as a binder in direct compression, dry granulation, or wet granulation, resulting in hard, non-friable tablets.
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features and benefits - excellent thermoplastic properties for HME or direct compression
- amorphous solid dispersion stabilizer
- compatible with most plasticizers
applications - tablet binding
- drug solubilization
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