Oral Solid Dose

Prescriptions for successful solutions

While an apple a day keeps the doctor away (and the teacher happy) there comes a time, in almost everyone's life, when medication - in pill form - is needed.  Our knowledge of the structure function of polymers, combined with our extensive product line can help you bind, coat, dissolve, and effectively deliver complex drug molecules where and when they're needed - making medication easier to swallow.  And, easy to swallow medication often yields better patient compliance,  which, in turn, yields better outcomes for everyone - a winning scenario. From concept to commericialization, working with Ashland makes medicine, easy to swallow.

Ashland is unsurpassed in its ability to develop solutions for effective and efficient solutions to effectively deliver today's complex drug molecules where and when they are needed.  Our global centers of excellence and manufacturing sites that operate in accordance with cGMP standards along with various chemistries and technologies, all supported by a global team of research and development scientists, Ashland stands ready collaborate with you on new solutions to help take you from concept to commercialization.  Our solutions include:

  • Increasing the soluability of active pharmaceutical ingredients with low or no solubility
  • Designing controlled-release products to meet targeted release profiles
  • Reducing tablet size while maintaining active pharmaceutical ingredient load
  • Improving disintegration time of orally disintegrating tablets
  • Understanding implications of continuous oral dosage for manufacturing technology

Ongoing research provides a foundation for advanced technical solutions that continue to address these and other future formulation and manufacturing challenges. Ashland provides formulators with industry-changing technologies and unique opportunities for research and development collaboration.

Controlled Release
Ashland is the the global leader in providing cellulose derivatives to the pharmaceutical industry. The various degrees of hydrophilicity and molecular weights of our high-quality cellulosic polymers can help take the guesswork out of controlled-release formulations and provide flexibility to tailor release profiles. Ashland also offers an artificial, neural networking solution, CRWizard™ controlled-release expert tool for formulation or release-profile prediction. Our history of formulation development has generated an extensive data set that can be used to predict the best possible starting formulation for any active pharmaceutical ingredient.  To make use of our expertise, please contact us.

Tablet Binders
Binder selection is critical for robust tablet formulation. Through reasearch, Ashland gained a deeper understanding of the physics of tablet binding, which led to the development of practical tools to assist in binder selection. These tools combined with the exceptional range of Ashland binders, helps you minimize the risk of selecting the wrong binder. Ashland produces binders for wet granulation, dry granulation, direct compression and roller compaction to fit your manufacturing needs.

Bioavailability Enhancement
Poorly water-soluble active pharmaceutical ingredients (APIs) pose ongoing development challenges. Common techniques to improve API solubility, such as salt formation and particle-size reduction, do not always result in the solubility levels required to achieve desired bioavailability.

Ashland pharmaceutical scientists have extensive expertise in the development and manufacture of spray-dried and hot melt-extruded solid dispersions. Over the past 15 years, our contract-services group developed formulations for more than 100 poorly water-soluble compounds. Our Centers of Excellence in Wilmington, DE and Hydrabad, India, offer proof-of-concept services using enabling technologies such as spray drying and hot-melt extrusion. Our São Paulo, Brazil, technical center also offers assistance in evaluating Ashland polymers for hot-melt extrusion. Our technical service scientists are also available for on-site consultations.

Film Coatings
Ashland’s line of fully formulated, easily dispersed and ready-to-use Aquarius™ film-coating systems have a range of functions to suit almost any tablet core. Aquarius film-coating systems present an optimum balance of film strength and adhesion, even on challenging cores. The Aquarius Preferred HSP and HSC coating systems are sprayable at 20% solids, for faster throughput and reduced labor and energy costs compared with conventional, lower-solids coatings.
Aquarius film coating systems deliver a smooth, defect-free appearance complete with crisp logo definition in clear, white, pearlescent or full-color formulations and can be customized to address special needs.
- Improved adhesion
- Improved flexibility
- Moisture barrier
- Odor and taste masking
- Controlled/delayed release

Disintegrants
Effective tablet disintegration is necessary for active pharmaceutical ingredient (API) dissolution and release. Polyplasdone™ crospovidone, a synthetic, cross-linked polymer, provides rapid disintegration and dissolution of oral solid-dosage forms, even at low use levels; thus also making it effective for high dose formulations. Available in two particle sizes. it provides formulation flexibility for small and large tablets as well as intragranular and extragranular applications. Polyplasdone crospovidone combines rapid swelling with wicking (porosity and capillary action) mechanisms. The high compactability and rapid disintegration of Polyplasdone crospovidone make it a good choice as a multifunctional tablet disintegrant.
Unlike other disintegrants that can gel at high use levels, Polyplasdone crospovidone does not retard API release making it especially beneficial for orally disintegrating tablet (ODT) formulations that have short disintegration time requirements.

Because of its nonionic nature, Polyplasdone crospovidone does not impede dissolution of cationic APIs Polyplasdone XL-10 crospovidone offers uncommon benefits:
 - small particle size and rapid disintegration make it a preferred product for  (ODT) formulations.
 - a high surface area and unique chemistry that enhances the dissolution of poorly water-soluble APIs when compared with other disintegrants.

Polyplasdone Ultra crospovidone is high-purity crospovidone, manufactured and packed under inert conditions for use with active pharmaceutical ingredients that may be sensitive to oxidation or as a precaution where this may be a concern. To preserve the integrity of the inert environment, please refer to the product sampling and handling guidelines.

 

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Aqualon™ ethylcellulose Aquarius™ film coating systems Aquasolve™ hypromellose acetate succinate Benecel™ methylcellulose and hypromellose Blanose™ sodium carboxymethylcellulose CAVAMAX™ native cyclodextrins Klucel™ hydroxypropylcellulose Natrosol™ hydroxyethylcellulose Aqualon™ sodium carboxymethylcellulose Plasdone™ povidone Plasdone™ S-630 copovidone Polyplasdone™ crospovidone Pharmasolve™ N-methyl-2-pyrrolidone