Cavitron™ and Cavasol* hydroxypropyl-ß-cyclodextrins (HPBCD)
The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native ß-CD to make hydroxypropyl-ß-cyclodextrins significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the Cavasol hydroxypropyl-ß-cyclodextrins capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation, and also can increase solubility of poorly soluble compounds in oral drug delivery systems. Purification of the Cavitron cyclodextrins to remove endotoxins allows their use for solubilization of drugs for injectable drug products.
The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).
*Cavasol is a registered trademark owned by Wacker Chemie AG. Ashland Inc. acts as a worldwide distributor for Wacker.
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- Asia Pacific
- Europe, Middle East, Africa, India
- Latin America and South America
- North America
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Increases solubility of poorly soluble active pharmaceutical ingredients in aqueous media via the hydrophilic exterior of the cyclodextrin in the inclusion complex. The pyrogen-free hydroxypropyl derivative increases water solubility of the drug/cyclodextrin complex and enables the cyclodextrin to be used in injectable drug formulations.
• Increase bioavailability of poorly soluble drugs in oral solid and liquid dosage
• Enhance solubility of poorly soluble drugs in parenteral dosage forms
Through encapsulation within the cyclodextrin cavity, molecules of specific functional groups that cause unpleasant taste and odor are hidden from sensory receptors.
• Improve patient compliance through taste and odor masking
• Stabilize drug against light, temperature, oxidation
• Inhibit drug-ingredient interaction
Through encapsulation within the cyclodextrin cavity, molecules that are prone to degradation can be protected and stabilized.
• Stabilize drug against light, temperature, oxidation
• Inhibit drug-ingredient interaction
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