Cavitron™ and CAVASOL* hydroxypropyl-ß- and
hydroxypropyl-γ-cyclodextrins (HPBCD and HPGCD)

The molecular structure of cyclodextrins creates a bucket-like cavity that can function to complex with molecules or functional groups on molecules. The substitution of hydroxyl groups on native cyclodextrins to make hydroxypropyl-ß- or hydroxypropyl-γ-cyclodextrins (HPBCD or HBGCD) significantly enhances their solubility and makes them more suitable for drug solubilization. This mechanism makes the CAVASOL HPBCDs and HPGCDs capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation, and also can increase solubility of poorly soluble compounds in oral drug delivery systems. Purification of the Cavitron cyclodextrins to remove endotoxins allows their use for solubilization of drugs for injectable drug products.

The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).

*CAVASOLis a registered trademark owned by Wacker Chemie AG. Ashland Inc. acts as a worldwide distributor for Wacker.

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Application Information




Drug Solublization

Increases solubility of poorly soluble active pharmaceutical ingredients in aqueous media via the hydrophilic exterior of the cyclodextrin in the inclusion complex. The pyrogen-free hydroxypropyl derivative increases water solubility of the drug/cyclodextrin complex and enables the cyclodextrin to be used in injectable drug formulations.

  • Increase bioavailability of poorly soluble drugs in oral solid and liquid dosage
  • Enhance solubility of poorly soluble drugs in parenteral dosage forms



Through encapsulation within the cyclodextrin cavity, molecules that are prone to degradation can be protected and stabilized.


Taste and Odor Masking Agent
Through encapsulation within the cyclodextrin cavity, molecules of specific functional groups that cause unpleasant taste and odor are hidden from sensory receptors.

  • Stabilize drug against light, temperature, oxidation
  • Reduce GI tract irritation
  • Simplify handling by converting oils and liquids to powders
  • Inhibit drug-ingredient interaction
  • Improve patient compliance through taste and odor masking


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Market Information



Product Types or Functions

Drug Solublization, Other
Solubilizer, Solubilizer for Injectables, Stabilizer, Taste Masking