Benecel™ methylcellulose and hypromellose

Benecel methylcellulose and hypromellose (hydroxypropyl-methylcellulose or HPMC) are versatile excipients with a variety of applications.

High-viscosity grades are widely used in hydrophilic matrix controlled-release systems. Low-viscosity grades are used as the primary film former in tablet coatings and vegetarian capsule formulations, and are a common wet-granulation tablet binder.

Hypromellose is used as a solid dispersions solubilizer in spray-dried or melt-extruded formulations.

Custom intermediate-molecular weight grades

Achieving a desired drug-release profile has traditionally involved blends of different molecular weights of particular polymers. Blending can increase release-profile variability. Benecel K250 PH PRM, K750 PH PRM and K1500 PH PRM HPMC were developed to obviate the need for blending and offer a potential solution to the problem of dissolution variability.

Custom Benecel hypromellose grades for controlled-release tablets

Directly compressible grades

Directly compressible (DC) grades enable controlled-release formulations with the convenience of the most widely used tablet binding mechanism. These Benecel DC HPMC grades offer good powder flow, content uniformity and compressibility, making them well suited for direct compression.

The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).

Directly compressible Benecel PH DC hypromellose
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Application Information




Controlled-release Formulations

High-viscosity grades are common gel-forming polymers for hydrophilic matrix tablets. Custom intermediate-molecular weight grades can reduce the need for blending to achieve a desired release profile. Directly compressible grades enable controlled-release formulations with this convenient tablet binding mechanism.

  • Strong gel formation
  • Good powder flow
Drug Solublization

Enhances bioavailability and stability.

• Hydrogen bond acceptor and donator
• Superior stabilizer and supersaturation inhibitor
• Chemically inert
• Non-pH dependent dissolution
• Excellent safetyprofile with clinical precedence


Rheology Modification
Can be used to thicken suspensions and syrups.

• Thickens in cold water
• Suspends particulates

Tablet Binding

Low-viscosity grades are used in wet granulation.

• Good binding efficiency
• Low viscosity allows for high concentrations

Tablet Film Coating

Low-viscosity Benecel HPMC is a widely used film former for tablet coatings.

• Low viscosity with good film strength
• Compatible with pigments, plasticizers, and other coating additives

Document Library

Additional Information

Substitution Type     Benecel HPMC Grade     Nominal Viscosity (mPa·s)(a)
Methylcellulose       A15 LV PH PRM       12-18
        A15C Pharm       1,125-2,100
        A4M Pharm       3,000-5,600
 Hypromellose 2910       E4M Pharm       2,700-5,040
        E10M Pharm1       7,500-14,000
Hypromellose 2906       F4 Pharm       3-5
Hypromellose 2208       K100LV PH PRM2       80-120
        K250 PH PRM2       200-300
        K750 PH PRM2       600-900
        K1500 PH PRM2       1,200-1,800
        K4M Pharm1       2,700-5,040
        K4M PH DC1       2,700-5,040
        K15M Pharm1       13,500-25,200
        K15M PH DC1       13,500-25,200
        K35M Pharm1       26,250-49,000
        K100M Pharm1       75,000-140,000
        K200M Pharm1       150,000-280,000
Methylhydroxyethyl       ME 50 PH PRM2       38-70
        ME 350 PH PRM2       262-490
        ME 233 Pharm       3,100-5,700

(a)USP/EP/JP viscosity method
1CR Grades available
2Only CR grades available

Market Information



Product Types or Functions

Controlled-release Formulations, Drug Solublization, Other, Tablet Binding, Tablet Film Coating
Coating Polymer, Immediate-release Binder, Modified-release Binder, Rheology Modifier