Benecel™ methylcellulose and hypromellose
Benecel methylcellulose and hypromellose (hydroxypropyl-methylcellulose or HPMC) are versatile excipients with a variety of applications.
High-viscosity grades are widely used in hydrophilic matrix controlled-release systems. Low-viscosity grades are used as the primary film former in tablet coatings and vegetarian capsule formulations, and are a common wet-granulation tablet binder.
Hypromellose is used as a solid dispersions solubilizer in spray-dried or melt-extruded formulations.
Custom intermediate-molecular weight grades
Achieving a desired drug-release profile has traditionally involved blends of different molecular weights of particular polymers. Blending can increase release-profile variability. Benecel K250 PH PRM, K750 PH PRM and K1500 PH PRM HPMC were developed to obviate the need for blending and offer a potential solution to the problem of dissolution variability.
Custom Benecel hypromellose grades for controlled-release tablets
Directly compressible grades
Directly compressible (DC) grades enable controlled-release formulations with the convenience of the most widely used tablet binding mechanism. These Benecel DC HPMC grades offer good powder flow, content uniformity and compressibility, making them well suited for direct compression.
The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).
Directly compressible Benecel PH DC hypromellose
High-viscosity grades are common gel-forming polymers for hydrophilic matrix tablets. Custom intermediate-molecular weight grades can reduce the need for blending to achieve a desired release profile. Directly compressible grades enable controlled-release formulations with this convenient tablet binding mechanism.
- Strong gel formation
- Good powder flow
Enhances bioavailability and stability.
• Hydrogen bond acceptor and donator
• Superior stabilizer and supersaturation inhibitor
• Chemically inert
• Non-pH dependent dissolution
• Excellent safetyprofile with clinical precedence
Can be used to thicken suspensions and syrups.
• Thickens in cold water
• Suspends particulates
Low-viscosity grades are used in wet granulation.
• Good binding efficiency
• Low viscosity allows for high concentrations
Low-viscosity Benecel HPMC is a widely used film former for tablet coatings.
• Low viscosity with good film strength
• Compatible with pigments, plasticizers, and other coating additives
Product Literature(publicly available)
Additional Product Literature
Safety Data Sheets
- Product Information
- Controlled Release with Custom Grades of Benecel™ HPMC
- Benecel™ Methylcellulose and Hypromellose
- Technology Reports
- Dissolution Performance and Robustness of New Hypromellose Controlled-release Polymers
|Substitution Type||Benecel HPMC Grade||Nominal Viscosity (mPa·s)(a)|
|Methylcellulose||A15 LV PH PRM||12-18|
|Hypromellose 2910||E4M Pharm||2,700-5,040|
|Hypromellose 2906||F4 Pharm||3-5|
|Hypromellose 2208||K100LV PH PRM2||80-120|
|K250 PH PRM2||200-300|
|K750 PH PRM2||600-900|
|K1500 PH PRM2||1,200-1,800|
|K4M PH DC1||2,700-5,040|
|K15M PH DC1||13,500-25,200|
|Methylhydroxyethyl||ME 50 PH PRM2||38-70|
|ME 350 PH PRM2||262-490|
|ME 233 Pharm||3,100-5,700|
(a)USP/EP/JP viscosity method
1CR Grades available
2Only CR grades available