Benecel™ methylcellulose and hypromellose
Benecel methylcellulose and hypromellose (hydroxypropylmethylcellulose or HPMC) are versatile excipients.
High-viscosity grades are widely used in hydrophilic matrix controlled release systems. Low-viscosity grades are used as the primary film former in tablet coatings and vegetarian capsule formulations, and are a common wet-granulation tablet binder.
The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).
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- Asia Pacific
- Europe, Middle East, Africa, India
- Latin America and South America
- North America
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High-viscosity grades are common gel-forming polymers for hydrophilic matrix tablets.
• Strong gel formation
Can be used to thicken suspensions and syrups.
• Thickens in cold water
• Suspends particulates
Low-viscosity grades are used in wet granulation.
• Good binding efficiency
• Low viscosity allows for high concentrations
Low-viscosity Benecel HPMC is a widely used film former for tablet coatings.
• Low viscosity with good film strength
• Compatible with pigments, plasticizers, and other coating additives
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| USP Substitution Type | Benecel HPMC Grade | Nominal Viscosity (mPa·s)(a) |
| Methylcellulose | A15 LV PH PRM | 12-18 |
| A15C Pharm | 1,125-2,100 | |
| A4M Pharm | 3,000-5,600 | |
| 2910 | E3 Pharm | 2.4-3.6 |
| E5 Pharm | 4.0-6.0 | |
| E6 Pharm | 4.8-7.2 | |
| E15 PH | 12-18 | |
| E50 PH | 40-60 | |
| E4M Pharm | 2,700-5,040 | |
| E10M Pharm1 | 7,500-14,000 | |
| 2906 | F4 Pharm | 3-5 |
| 2208 | K100LV PH PRM2 | 80-120 |
| K250 PH PRM2 | 200-300 | |
| K750 PH PRM2 | 600-900 | |
| K1500 PH PRM2 | 1,200-1,800 | |
| K4M Pharm1 | 2,700-5,040 | |
| K15M Pharm1 | 13,500-25,200 | |
| K35M Pharm1 | 26,250-49,000 | |
| K100M Pharm1 | 75,000-140,000 | |
| K200M Pharm1 | 150,000-280,000 | |
| Methylhydroxyethyl | ME 50 PH PRM2 | 38-70 |
| ME 350 PH PRM2 | 262-490 | |
| ME 233 Pharm | 3,100-5,700 |
(a)NF/EP/JP viscosity method
1CR Grades available
2Only CR grades available