Ashland published innovation papers

Ashland solvers have contributed innovations that have been publicly recognized. Some of these are published and available for review. See the table below for links to these documents. 

title/description authors related technologies related business unit
Investigation of the interactions of cationic guar with human hair by electrokinetic analysis McMullen, Roger L., Donna Laura, Guojin Zhang, and Bert Kroon  polysaccharides personal care
Evaluation of the surface properties of hair with acoustic emission analysis McMullen, Roger L., Tyler Schiess, Lidia Kulcsar, Linda Foltis, and Timothy Gillece measurement science personal care
The aim of this study was to develop a hydrophilic oral controlled release system (CRS) using the amorphous form of gliclazide, a BCS class II compound, listed on the WHO list of essential medicines. For this purpose, spray-dried dispersions (SDDs) of gliclazide were produced using various grades of hydroxypropyl methylcellulose acetate succinate (HPMCAS) or copovidone as carrier under fully automated conditions Lu, Zheng, Yonglai Yang, Rae-Ann Covington, Yunxia Vivian Bi, Thomas Dürig, and Reza Fassihi polysaccharides, acetylenics life sciences

Pollution damage and protection of Asian hair

Cigarette smoke was used to simulate a polluted environment and an experiment was performed to reveal how virgin and bleached hair are damaged by a polluted environment. The dry/wet combability, surface contact angle, tryptophan content, and cuticle morphology of the smoke exposed hair were evaluated, and compared to unexposed virgin hair. The results showed that pollution exposure can cause significant chemical damage to hair. In particular, virgin hair exposure to pollution can cause damage to the hair cuticles (higher wet/dry combing), protein degradation, and a more hydrophilic hair surface. The experiment also demonstrated that the styling polymer, polyimide-1 (isobutylene/dimethyl amino propyl maleimide/ethoxylated maleimide/maleic acid copolymer), can provide effective protection against such hair damage. 

 Qu, Xin, Lijuan Niu, Bert Kroon, and Linda Foltis acetylenics personal care
Hydrophobically Modified Isosorbide Dimethacrylates as a Bisphenol-A (BPA)-Free Dental Filling Material     Marie, Bilal, Raymond Clark, Tim Gillece, Seher Ozkan, Michael Jaffe, and Nuggehalli M. Ravindra acetylenics personal care
RAFT dispersion polymerization of N, N-dimethylacrylamide in a series of n-alkanes using a thermoresponsive poly (tert-octyl acrylamide) steric stabilizer     Gibson, R. R., A. Fernyhough, O. M. Musa, and S. P. Armes acetylenics core R&D
Synthesis of poly (vinyl alcohol‐graft‐hyperbranched glycerol)     King, Peter A., Ezat Khosravi, and Osama M. Musa acetylenics core R&D
Synthesis of well-defined diblock copolymer nano-objects by RAFT non-aqueous emulsion polymerization of N-(2-acryloyloxy) ethyl pyrrolidone in non-polar media     Gibson, R. R., A. Fernyhough, O. M. Musa, and S. P. Armes acetylenics core R&D
Introduction to Pyrrolidone and Caprolactam Chemistry Chenault, H. Keith acetylenics core R&D
Cocrystals, Coamorphous Phases and Coordination Complexes of γ-and ε-Lactams Hall, Amy V., Luke I. Chambers, Osama M. Musa, and Jonathan W. Steed acetylenics life sciences

Rheological Fingerprinting as an Effective Tool to Guide Development of Personal Care Formulations

A non-linear rheological technique termed LAOS was utilized to capture the textural expression perceived by consumers. Lissajous plots (stress vs. strain or strain rate) provide a fingerprint of the formula and are utilized to both analyse the thickening mechanism and monitor the influence of various parameters, such as the chemistry, molecular properties, colloidal parameters and processing conditions

 Ozkan, Seher & Alonso, Coralie & McMullen, Roger measurement science personal care 

Characterization of yield stress and slip behaviour of skin/hair care gels using steady flow and LAOS measurements and their correlation with sensorial attributes

Gels made with three different polymers widely used as rheology modifiers in cosmetic formulations (cross-linked poly(acrylic acid), cross-linked poly(maleic acid-alt-methyl vinyl ether) copolymer and cross-linked poly(acrylic acid-co-vinyl pyrrolidone) copolymer) were characterized by rheological and sensory evaluation methods to determine the relationship between sensorial perception and corresponding rheological parameters.

 Ozkan, S., Gillece, T.W., Senak, L. and Moore, D.J. acetylenics personal care
Development of carvedilol-cyclodextrin inclusion complexes using fluid-bed granulation: a novel solid-state complexation alternative with technological advantages Ellen C P Alonso, Karina Riccomini, Luis Antônio D Silva, Daniela Galter, Eliana M Lima, Thomas Durig, Stephania F Taveira, Felipe Terra Martins, Marcílio S S Cunha-Filho, Ricardo N Marreto polysaccharide life sciences
The preparation of graft copolymers of cellulose and cellulose derivatives using ATRP under homogeneous reaction conditions Joubert, F., Musa, O. M., Hodgson, D. R. W., & Cameron polysaccharide life sciences
Flexidone™ - A New Class of Innovative PVC Plasticizers Martin Bonnet and Hasan Kaytan acetylenics personal care
Cyclodextrin-Efavirenz Complexes Investigated by Solid State and Solubility Studies Braga, Susana S., Karyna Lysenko, Firas El-Saleh, and Filipe A.A. Paz polysaccharide life sciences
Radiochromic Film as a Tool for Development of Sun Protection Duev, A., Dueva-Koganov, O. V., Shih, S., Crohn, R., Aydin, R., & Menchon, M.  acetylenics life sciences
Is It Possible to Publish a Calibration Function for Radiochromic Film?     Chan, Maria F., Lewis D., Xiang Yu acetylenics life sciences
Inclusion Compound of Efavirenz and γ-Cyclodextrin: Solid State Studies and Effect on Solubility Braga, S. S., El-Saleh, F., Lysenko, K., & Paz, F. A. A. acetylenics life sciences

Hot Melt Extrudates Formulated Using Design Space: One Simple Process for Both Palatability and Dissolution Rate Improvement

This work aimed at obtaining an optimized itraconazole (ITZ) solid oral formulation in terms of palatability and dissolution rate by combining different polymers using hot melt extrusion (HME), according to a simplex centroid mixture design. For this, the polymers Plasdone® (poly(1-vinylpyrrolidone-co-vinyl acetate) [PVP/VA]), Klucel® ELF (2-hydroxypropyl ether cellulose [HPC]), and Soluplus® (SOL, polyvinyl caprolactam-polyvinyl acetate-polyethylene glycol) were processed using a laboratory HME equipment operating without recirculation at constant temperature.    

 Malaquias, L. F. B., Schulte, H. L., Chaker, J. A., Karan, K., Durig, T., Marreto, R. N., Gratieri, T., Gelfuso, G. M., & Cunha-Filho polysaccharides, acetylenics life sciences

Synthesis and Aqueous Solution Properties of Shape-Shifting Stimulus-Responsive Diblock Copolymer Nano-Objects. 

We report the synthesis of poly(N-(2-acryloyloxyethyl)pyrrolidone)-poly(4-hydroxybutyl acrylate) (PNAEP85-PHBAx) diblock copolymer nano-objects via reversible addition–fragmentation chain transfer (RAFT) aqueous dispersion polymerization of 4-hydroxybutyl acrylate (HBA) at 30 °C using an efficient two-step one-pot protocol.     

 Deane, O. J., Jennings, J., Neal, T. J., Musa, O. M., Fernyhough, A., & Armes acetylenics core R&D

Influence of various environmental parameters on sweat gland activity

Our initial goal in this work was to develop an in-house procedure to test the effi cacy of
antiperspirant products using replica techniques in combination with image analysis

 Mcmullen, R. L., Gillece, T., Lu, G., Laura, D., & Chen, S.  measurement science personal care 
Investigation of the internal structure of human hair with atomic force microscopy McMullen, R., & Zhang, G. measurement science personal care

A Pilot Study to Evaluate the Effects of Topically Applied Cosmetic Creams on Epidermal Responses

The objective of this study was to evaluate the changes in epidermal properties and inflammatory mediators after 4 days of topical application of 2 different polymers formulated in cosmetic creams.    

 Kelchen M, N, Menon G, Ten Eyck P, Prettypaul D, Brogden N, K measurement science personal care
Pluronics-Formulated Farnesol Promotes Efficient Killing and Demonstrates Novel Interactions with Streptococcus mutans Biofilms     Mogen AB, Chen F, Ahn SJ, Burne RA, Wang D, et al. functional molecules life sciences
Synthen and Pickering emulsifier performance of poly (stearyl methacrylate)–poly (N-2-(methacryloyloxy) ethyl pyrrolidone) diblock copolymer nano-objects via RAFT dispersion polymerisation in n-dodecane Cunningham, V. J., S. P. Armes, and O. M. Musa. acetylenics core R&D

Assessment of Polymeric Nanoparticles to Enhance Oral Bioavailability and Antioxidant Activity of Resveratrol

To enhance oral bioavailability and antioxidant potential of resveratrol by fabricating the resveratrol encapsulated oral eudragit® E100 based polymeric nano-delivery system.    
 

 Hasija, R., S. Chaurasia, and Swati Gupta acetylenics life sciences
Synthesis of Well-Defined Pyrrolidone-Based Homopolymers and Stimulus-Responsive Diblock Copolymers via RAFT Aqueous Solution Polymerization of 2-(N-Acryloyloxy)ethylpyrrolidone     Deane, O. J., Lovett, J. R., Musa, O. M., Fernyhough, A., & Armes, S. P. acetylenics core R&D

Supremely elastic gel polymer electrolyte enables a reliable electrode structure for silicon-based anodes

We utilized a soft ether-based domain, poly(tetramethylene ether) glycol (PTMG), and a hard cyclic ring-based domain, 4,4’-methylene diphenyl diisocyanate)-ethylenediamine (MDI-EDA), to compose the copolymer for GPE    
 

 Huang, Q., Song, J., Gao, Y., Peng S., Goliaszewski, A.     polyethers personal care s
Modulation of a Specific Pattern of microRNAs, Including miR-29a, miR-30a and miR-34a, in Cultured Human Skin Fibroblasts, in Response to the Application of a Biofunctional Ingredient that Protects against Cellular Senescence in Vitro Yan, X. , Serre, C. , Bergeron, L. , Mur, L. , Busuttil, V. , Botto, J. and Domloge, N. biofunctionals personal care
Determination of physicochemical properties of delipidized hair    Koelmel, D., & Zhang, G. Roger L McMullen, et al measurement science personal care 
Resveratrol-Loaded Poly(d,l-Lactide-Co-Glycolide) Microspheres Integrated in a Hyaluronic Acid Injectable Hydrogel for Cartilage Regeneration Wang, X., Li, X., Duffy, P., McMahon, S., Wang, X., Lyu, J., Xu, Q., A, S., Chen, N.N., Bi, V., Dürig, T. and Wang, W. polyesters life sciences
RAFT Aqueous Dispersion Polymerization of N-(2-(Methacryloyloxy)ethyl)pyrrolidone: A Convenient Low Viscosity Route to High Molecular Weight Water-Soluble Copolymers Cunningham, V. J., Derry, M. J., Fielding, L. A., Musa, O. M., & Armes, S. P. acetylenics core R&D
Poly(glycerol monomethacrylate)–Poly(benzyl methacrylate) Diblock Copolymer Nanoparticles via RAFT Emulsion Polymerization: Synthesis, Characterization, and Interfacial Activity Cunningham, V. J., Alswieleh, A. M., Thompson, K. L., Williams, M., Leggett, G. J., Armes, S. P., & Musa, O. M acetylenics core R&D

Fabrication of Taste-Masked Donut-Shaped Tablets Via Fused Filament Fabrication 3D Printing Paired with Hot-Melt Extrusion Techniques

The formulations without Eudragit E PO (F6) and with Eudragit E PO (F7) filaments exhibited the desired hardness with a “k” value of 48.30 ± 3.52 and 45.47 ± 3.51 g/mm3 (n = 10), respectively, and were successfully printed.

 Wang, H., Dumpa, N., Bandari, S. Durig, H acetylenics life sciences
Fluorescence in keratin tissues     McMullen, Roger L; Chen, Susan; Moore, David J measurement science personal care

Investigation of the interactions of enteric and hydrophilic polymers to enhance dissolution of griseofulvin following hot melt extrusion processing

Binary, ternary and quaternary dispersions containing GF, enteric polymer (Eudragit L100-55 or AQOAT-LF) and/or vinyl pyrrolidone-based polymer (Plasdone K-12 povidone or S-630 copovidone) were processed by HME.

 Ryan C Bennett, Justin M Keen, Yunxia (Vivian) Bi, Stuart Porter, Thomas Dürig, James W McGinity acetylenics life sciences