Polyplasdone™ crospovidone

Polyplasdone crospovidone superdisintegrants are synthetic, insoluble, but rapidly swellable, crosslinked homopolymers of N-vinyl-2-pyrrolidone. Crospovidone provides rapid disintegration and dissolution to oral solid dosage forms. Polyplasdone crospovidone particles are granular and porous compared with other superdisintegrants. The high surface area combined with unique chemistry results in high interfacial activity that enhances the dissolution of poorly soluble drugs in a way that is not possible with other disintegrant technologies.

The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).

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Application Information

Applications

Description

Benefits

Drug Solublization

Used as a solid dispersion carrier for drug solubilization, or incorporated into conventional formulations to facilitate the dissolution of poorly soluble active pharmaceutical ingredients due to porous surface morphology, large surface area and N-methyl vinylpyrrolidone-like unit molecular structure.

  • Enhances solubility/dissolution of poorly soluble drugs, especially at higher use levels.
Tablet Disintegration

Combines rapid swelling, wicking (due to porosity and capillary action) and particle recovery on wetting, releasing energy that facilitates disintegration. High interfacial activity enhances dissolution.

Used as a solid dispersion carrier for drug solubilization, or incorporated into conventional formulations to facilitate the dissolution of poorly soluble active pharmaceutical ingredients due to porous surface morphology, large surface area and N-methyl vinylpyrrolidone-like unit molecular structure.

  • Two key particle sizes (small particle size especially suitable for orally disintegrating tablet dosage forms)
  • High compressibility for use with poorly compressible drugs
  • Intragranular or extragranular application
  • Non-ionic for superior cationic drug dissolution
  • Does not gel, so will not retard release of drug

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Market Information

Markets

Application

Product Types or Functions

Pharmaceutical
Drug Solublization, Tablet Disintegration
Tablet Superdisintegrant