Pharmasolve™ N-methyl-2-pyrrolidone

Pharmasolve N-methyl-2-pyrrolidone (NMP) is a water-miscible polar aprotic solvent with high interfacial activity. It is used as a drug solubilizer and penetration enhancer in human topical dosage forms, and for the same purposes in parenteral and topical veterinary products.

The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).

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Application Information




Drug Solublization

Drug solubilizer and penetration enhancer in topical dosage forms. Enhanced solubility is seen in select drugs when Pharmasolve NMP is included in the formulation, because of the polar nature of the molecule.

  • In topical applications, improves solubility of a wide range of water-insoluble drug actives

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Market Information



Product Types or Functions

Drug Solublization