CAVAMAX* native cyclodextrins
The molecular structure of cyclodextrins creates a bucket-like cavity that can complex with molecules or functional groups on molecules to improve solubility of poorly soluble compounds. The same mechanism makes these excipients capable of masking unpleasant taste/odor and stabilizing drugs that are prone to degradation. The number of glucose units in the ring determines the internal diameter of the cavity and its volume, as the height of the cyclodextrin cavity is the same for all the native cyclodextrin grades.
CAVAMAX cyclodextrins are biocompatible and compatible with a wide range of ingredients commonly used in pharmaceutical applications. The regulatory compliance information for all Ashland products varies by product family and grade. For specific data about the grade you are interested in please refer to our Excipient Information Package and the Certificate of Analysis (COA).
*CAVAMAX is a registered trademark owned by Wacker Chemie AG. Ashland Inc. acts as a worldwide distributor for Wacker.
Forms inclusion complexes with poorly soluble drug substances, with the effect of increasing drug solubility in aqueous media via the hydrophilic exterior of the cyclodextrin in the inclusion complex.
- Increase bioavailability of poorly soluble drugs in oral solid and liquid dosage forms
Through encapsulation within the cyclodextrin cavity, molecules that are prone to degradation can be protected and stabilized.
Through encapsulation within the cyclodextrin cavity, molecules of specific functional groups that cause unpleasant taste and odor are hidden from sensory receptors.
- Stabilize drug against light, temperature, oxidation
- Reduce GI tract irritation
- Simplify handling by converting oils and liquids to powders
- Inhibit drug-ingredient interaction
- Improve patient compliance through taste and odor masking