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New help in the fight against cellulite

Proteins cause slimming effect in noninvasive, nonsurgical application

The U.S. Patent and Trademark Office has issued patent No. 8,012,938 to Claude Dal Farra, vice president, Technology, Ashland Specialty Ingredients; Nouha Domloge, M.D., director, Vincience R&D and Jean-Marie Botto, Ph.D., senior manager, Vincience R&D Material Science.

What is it?
Titled "Dermatological and/or cosmetic composition containing polypeptides," the patented composition uses proteins in the UCP family as active agents in a pharmaceutical, dermatological and/or cosmetic application.

"UCP" refers to a family of uncoupling proteins found in a variety of human tissues, such as intestines, skeletal muscles and the brain, as well as immune system cells. UCP proteins play a significant role in energy metabolism and the metabolic regulation of food.

Significant gene therapy research has been conducted into the use of UCP proteins to treat genetic dysfunctions and diseases related obesity and diabetes. The team's patented composition uses those proteins as active ingredients in an entirely new way.

 
The proteins in the composition help reduce triglycerides

Applications
When applied to the skin, these UCP proteins cause a slimming effect, reducing, eliminating and preventing excessive subcutaneous fat. UCP proteins open new prospects, particularly in topical use to fight cellulite.

Cellulite is a particular configuration of fat, causing skin to appear dimpled and lumpy in certain areas of the body such as the hips, thighs, buttocks, knees and forearms. At an advanced stage of cellulite formation, the skin spontaneously takes on an orange peel or dimpled appearance.

Excessive triglyceride storage can generate enlarged fat cells, and thus, body fat. The proteins in the patented composition significantly contribute to a decrease in the quantity of triglycerides contained in the skin's body fat. So, with the composition, the skin gradually regains its normal appearance and does not develop cellulite tissue.

Benefits
The team's patent, using UCP proteins as active ingredients, makes it possible to prevent and treat the appearance of cellulite.

One of patent's benefits is the variety of ways it can be used. The compositions can take the form of a cream, suspension or powder, adapted for application to the skin, mucous membranes, lips, hair and nails. They can also be applied in lotions, milks, serums, ointments, shampoos, gels, pastes and mousse, or key ingredients in skin care products.

Another advantage of the team's invention is that it offers an effective topical treatment against body fat while using noninvasive, nonsurgical and relatively inexpensive methods.